What do you mean? Is there an error message?
More often than not, most problems have to do with memory. Most memory problems have to do with the program trying to load too much content. Therefore, you might do this 1. Delete all dem files - they're only eye-candy anyway. 2. Reduce or delete the speedcams area. 3. Limit the amount of maps to what you really need. 4. POIs - see #3. 5. Delete the buildings and landmarks. 6. You might not be able to have TTS. Try the others first and then I'll instruct regarding TTS.